On February 25th and 26th of 2013, the Institute of Medicine convened a roundtable discussion on value and science-driven health care. Workshop discussions focused on building insights and recognition on the necessity of increased patient, family, and citizen engagement in achieving better outcomes and lower costs in health care; exploring what has been learned about effective approaches for building patient demand and involvement in improving evidence, care, and value—including principles and barriers; considering strategies and policies for activities to be undertaken at multiple levels to advance patients, in partnership with providers, as leaders and drivers of care delivery improvement through the protected use of clinical data, informed, shared decisions, and value improvement; and identifying important research opportunities for developing the additional insights needed to accelerate progress.