To inform a forthcoming rapid expert consultation on building public confidence in SARS-CoV-2 vaccines, the Societal Experts Action Network (SEAN) of the National Academies of Sciences, Engineering, and Medicine will hold an information gathering session on vaccine confidence. The session will cover the current state of vaccine confidence, reasons for hesitancy, and best practices for messaging. Facilitated discussions will incorporate special attention to communities at higher risk of contracting and dying from COVID-19, including underserved and vulnerable communities. Drawing from what is known about reaching and engaging diverse audiences to change beliefs and attitudes, this session will illustrate strategies that are likely to promote uptake of FDA-approved vaccines to prevent COVID-19.